Detoxification in rehabilitation in England: effective continuity of care or unhappy bedfellows?

There is evidence that residential detoxification alone does not provide satisfactory treatment outcomes and that outcomes are significantly enhanced when clients completing residential detoxification attend rehabilitation services (Gossop, Marsden, Stewart, & Rolfe, 1999; Ghodse, Reynolds, Baldacchino, et al., 2002). One way of increasing the likelihood of this continuity of treatment is by providing detoxification and rehabilitation within the same treatment facility to prevent drop-out, while the client awaits a rehabilitation bed or in the transition process. However, there is little research evidence available on the facilities that offer both medical detoxification and residential rehabilitation. The current study compares self-reported treatment provision in 87 residential rehabilitation services in England, 34 of whom (39.1%) reported that they offered detoxification services within their treatment programmes. Although there were no differences in self-reported treatment philosophies, residential rehabilitation services that offered detoxification were typically of shorter duration overall, had significantly more beds and reported offering more group work than residential rehabilitation services that did not offer detoxification. Outcomes were also different, with twice as many clients discharged on disciplinary grounds from residential rehabilitation services without detoxification facilities. The paper questions the UK classification of residential drug treatment services as either detoxification or rehabilitation and suggests the need for greater research focus on the aims, processes and outcomes of this group of treatment providers

Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA

Groove specificity: Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA (see scheme). However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented

General Relativistic Simulations of Jet Formation in a Rapidly Rotating Black Hole Magnetosphere

To investigate the formation mechanism of relativistic jets in active galactic nuclei and micro-quasars, we have developed a new general relativistic magnetohydrodynamic code in Kerr geometry. Here we report on the first numerical simulation of jet formation in a rapidly-rotating (a=0.95) Kerr black hole magnetosphere. We study cases in which the Keplerian accretion disk is both co-rotating and counter-rotating with respect to the black hole rotation. In the co-rotating disk case, our results are almost the same as those in Schwarzschild black hole cases: a gas pressure-driven jet is formed by a shock in the disk, and a weaker magnetically-driven jet is also generated outside the gas pressure-driven jet. On the other hand, in the counter-rotating disk case, a new powerful magnetically-driven jet is formed inside the gas pressure-driven jet. The newly found magnetically-driven jet in the latter case is accelerated by a strong magnetic field created by frame dragging in the ergosphere. Through this process, the magnetic field extracts the energy of the black hole rotation.Comment: Co-rotating and counter-rotating disks; 8 pages; submitted to ApJ letter

Observation and uses of position-space Bloch oscillations in an ultracold gas

We report the direct observation and characterization of position-space Bloch oscillations using an ultracold gas in a tilted optical lattice. While Bloch oscillations in momentum space are a common feature of optical lattice experiments, the real-space center-of-mass dynamics are typically too small to resolve. Tuning into the regime of rapid tunneling and weak force, we observe real-space Bloch oscillation amplitudes of hundreds of lattice sites, in both ground and excited bands. We demonstrate two unique capabilities enabled by tracking of Bloch dynamics in position space: measurement of the full position-momentum phase-space evolution during a Bloch cycle, and direct imaging of the lattice band structure. These techniques, along with the ability to exert long-distance coherent control of quantum gases without modulation, may open up new possibilities for quantum control and metrology.Comment: 5 pages, 6 figure

Elementary solution to the time-independent quantum navigation problem

A quantum navigation problem concerns the identification of a time-optimal Hamiltonian that realizes a required quantum process or task, under the influence of a prevailing ‘background’ Hamiltonian that cannot be manipulated. When the task is to transform one quantum state into another, finding the solution in closed form to the problem is nontrivial even in the case of timeindependent Hamiltonians. An elementary solution, based on trigonometric analysis, is found here when the Hilbert space dimension is two. Difficulties arising from generalizations to higher-dimensional systems are discussed

In the Shadow of the Accretion Disk: Higher Resolution Imaging of the Central Parsec in NGC 4261

The physical conditions in the inner parsec of accretion disks believed to orbit the central black holes in active galactic nuclei can be probed by imaging the absorption (by ionized gas in the disk) of background emission from a radio counterjet. We report high angular resolution VLBI observations of the nearby (about 40 Mpc) radio galaxy NGC 4261 that confirm free-free absorption of radio emission from a counterjet by a geometrically thin, nearly edge-on disk at 1.6, 4.8, and 8.4 GHz. The angular width and depth of the absorption appears to increase with decreasing frequency, as expected. We derive an average electron density of ~10E4 per cc at a disk radius of about 0.2 pc, assuming that the inner disk inclination and opening angles are the same as at larger radii. Pressure balance between the thermal gas and the magnetic field in the disk implies an average field strength of 0.1 milligauss at a radius of 0.2 pc. These are the closest-in free-free absorption measurements to date of the conditions in an extragalactic accretion disk orbiting a black hole with a well-determined mass. If a standard advection-dominated accretion flow exists in the disk center, then the transition between thin and thick disk regions must occur at a radius less than 0.2 pc (4000 Schwarzschild radii).Comment: 20 pages including 12 figures. Accepted for publication in Ap

Down but not out: properties of the molecular gas in the stripped Virgo Cluster early-type galaxy NGC4526

We present ALMA data on the 3mm continuum emission, CO isotopologues (12CO, 13CO, C18O), and high-density molecular tracers (HCN, HCO+, HNC, HNCO, CS, CN, and CH3OH) in NGC4526. These data enable a detailed study of the physical properties of the molecular gas in a longtime resident of the Virgo Cluster; comparisons to more commonly-studied spiral galaxies offer intriguing hints into the processing of molecular gas in the cluster environment. Many molecular line ratios in NGC4526, along with our inferred abundances and CO/H2 conversion factors, are similar to those found in nearby spirals. One striking exception is the very low observed 12CO/13CO(1-0) line ratio, $3.4\pm0.3$, which is unusually low for spirals though not for Virgo Cluster early-type galaxies. We carry out radiative transfer modeling of the CO isotopologues with some archival (2-1) data, and we use Bayesian analysis with Markov chain Monte Carlo techniques to infer the physical properties of the CO-emitting gas. We find surprisingly low [12CO/13CO] abundance ratios of $7.8^{+2.7}_{-1.5}$ and $6.5^{+3.0}_{-1.3}$ at radii of 0.4 kpc and 1 kpc. The emission from the high-density tracers HCN, HCO+, HNC, CS and CN is also relatively bright, and CN is unusually optically thick in the inner parts of NGC4526. These features hint that processing in the cluster environment may have removed much of the galaxy's relatively diffuse, optically thinner molecular gas along with its atomic gas. Angular momentum transfer to the surrounding intracluster medium may also have caused contraction of the disk, magnifying radial gradients such as we find in [13CO/C18O]. More detailed chemical evolution modeling would be interesting in order to explore whether the unusual [12CO/13CO] abundance ratio is entirely an environmental effect or whether it also reflects the relatively old stellar population in this early-type galaxy.Comment: Submitted to ApJ. Comments are welcome